The synthesis of bilirubin glucuronide in animal and human liver.
نویسندگان
چکیده
PHOSPHORUS IN ESCHERICHIA COLI 705 Schachman, H. K., Pardee, A. B. & Stanier, R. Y. (1,952). Arch. Biochem. Biophys. 38, 245. Schmidt, C. F. (1948). J. Bact. 55, 705. Schmidt, G. & Thannhauser, S. J. (1945). J. biol. Chem. 161, 83. Sherratt, H. S. A. & Thomas, A. J. (1953). J. gen. Microbiol. 8, 217. Smellie, R. M. S., Maclndoe, W. M., Logan, R. & Davidson, J. N. (1953). Biochem. J. 54, 280. Tyner, E. P., Heidelberger, C. & LePage, G. A. (1953). Cancer Re8. 13, 186. Volkin, E. & Astrachan, L. (1956). Virology, 2, 433. Wade, H. E. (1952). J. gen. Microbiol. 7, 24. Wade, H. E. & Morgan, D. M. (1953). Nature, Lond., 174. 920. Wade, H. E. & Morgan, D. M. (1955). Biochem. J. 60, 264. Wade, H. E. & Morgan, D. M. (1957). Biochem. J. 65, 321.
منابع مشابه
Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice.
Regulation of bilirubin glucuronide transporters during hyperbilirubinemia in hepatic and extrahepatic tissues is not completely clear. In the present study, we evaluated the regulation of the bilirubin glucuronide transporters, multidrug resistance-associated proteins (MRP)2 and 3, in rats with obstructive jaundice. Bile duct ligation (BDL) or sham operation was performed in Wistar rats. Liver...
متن کاملHepatic microsomal bilirubin UDP-glucuronosyltransferase. The kinetics of bilirubin mono- and diglucuronide synthesis.
Hepatic biotransformation of bilirubin to the hydrophilic species bilirubin mono- (BMG) and diglucuronide (BDG) by microsomal bilirubin UDP-glucuronosyl-transferase (GT) is a prerequisite for its physiologic excretion into bile. The reaction mechanism of bilirubin-GT and the access of bilirubin and BMG (the intermediate substrate) to the active site of bilirubin-GT are undefined. Highly purifie...
متن کاملIdentification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil).
Posaconazole (Noxafil, SCH 56592), an orally available broad-spectrum triazole antifungal, is currently in phase III clinical studies for treating serious opportunistic fungal infections. The major in vitro metabolite of posaconazole formed by human liver microsomes supplemented with uridine 5'-diphosphate-glucuronic acid was a glucuronide of posaconazole (m/z877). Screening of 10 cDNA-expresse...
متن کاملGlucuronidation of HMR1098 in human microsomes: evidence for the involvement of UGT1A1 in the formation of S-glucuronides.
HMR1098, a novel KATP-blocking agent, is metabolized to form an S-glucuronide in rat and dog bile. Synthesis of the S-glucuronide metabolite was studied in human liver and kidney microsomes. Recombinant UPD-glucuronosyltransferases (UGTs) were screened for activity, and kinetic analysis was performed to identify the isoform or isoforms responsible for the formation of this novel S-glucuronide i...
متن کاملEfficacy of Silybum Marianum Seeds in Ameliorating the Toxic Effects of Aflatoxin B1 in Broilers
Background: This study aims to evaluate the efficacy of silybum marianum seeds (SMSs) on blood biochemical profile of broiler chickens contaminated with Aflatoxin B1 (AFB1). Methods: Combinations of three levels of AFB1 (0, 250 and 500 ppb) with three levels of SMSs (0, 0.5, and 1.0 %) were incorporated into the basal diet (corn and soybean meal). The effect of nine experimental treatments was...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Biochemical journal
دوره 70 4 شماره
صفحات -
تاریخ انتشار 1958